This work aims to optimize and assess the potential use of lipid nanoparticles, namely\nnanostructured lipid carriers (NLCs), as drug delivery systems of rifapentine (RPT) for the treatment of\ntuberculosis (TB). A Boxâ??Behnken design was used to increase drug encapsulation efficiency (EE) and\nloading capacity (LC) of RPT-loaded NLCs. The optimized nanoparticles were fully characterized, and\ntheir effect on cell viability was assessed. The quality-by-design approach allowed the optimization of\nRPT-loaded NLCs with improved EE and LC using the minimum of experiments.......................
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